Argireline

Pepoderma primary owner

Overview

On the INCI deck this active reads as Acetyl Hexapeptide-8 — the N-acetylated hexapeptide that has anchored the topical expression-line category since the early 2000s. The sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 was designed around the SNAP-25 protein of the SNARE complex: the proposed mechanism is competitive interference with SNARE assembly, the same neurotransmitter-release pathway the longer SNAP-8 (Acetyl Octapeptide-3) mimetic was built to engage. For a finished-product brand the marketing translation is the dynamic-line story — forehead, glabellar, periocular — carried in lightweight serums and creams meant to sit invisibly under makeup. Pepoderma writes the Argireline spec for indie founders and cosmetic chemists building expression-line serums, eye creams, and pre-makeup smoothing primers where a water-soluble peptide at a meaningful loading drives both the sensory and the COGS conversation. The active drops into the water phase cool and late on copper-clean process water; near-neutral carriers built on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave well, and pre-dissolving the powder in a small glycerin or propanediol slurry before bringing it to the main batch avoids clumping at the higher loadings the category tends to run. Because the dose-response of a topical peptide is gated by stratum-corneum partitioning rather than in-vitro receptor occupancy, the use level should be set against the claim and the retail price point together rather than pushed for its own sake. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale lots run on the standard OEM cycle once a carrier is locked. Argireline stacks naturally with SNAP-8 and Leuphasyl, which engage complementary expression-line pathways, and pairs with Matrixyl or GHK-Cu when a brief wants a signal or carrier arm alongside the neurotransmitter story. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic-notification workflows.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM, regional cosmetic-active distributors serving brand programmes, and skincare R&D chemists scoping a finished-product line.

Applications & formulation fit

Specifications

CAS

616204-22-9

Molecular Formula

C34H60N14O12S

Sequence

Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

Purity (HPLC)

≥ 99.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request (kilo-scale available)

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions