Snap-8

Pepoderma primary owner

Overview

On the INCI deck this active reads as Acetyl Octapeptide-3 — the eight-residue, N-acetylated peptide that extends Argireline (Acetyl Hexapeptide-8) by two residues onto the SNAP-25 mimetic surface. The sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 was designed to occupy more of the SNARE-binding face, working on the hypothesis that a longer mimetic competes more efficiently for SNAP-25 incorporation in vitro. For a finished-product brand the marketing translation is the expression-line story — forehead, glabellar, periocular — delivered in serums and creams that need to feel weightless under primer. Pepoderma writes the Snap-8 spec for indie founders and cosmetic chemists building expression-line serums, eye creams, and pre-makeup smoothing primers. Use level lands in the 5–10% window on finished-product mass; most brands settle near 5–8% once cost, sensory feel, and stack interactions are weighed. The active drops into the water phase cool and late on copper-clean process water; carriers built on polyglyceryl, lecithin, or sucrose-ester emulsifiers at neutral pH (5.5–7.0) behave well. Pre-dissolve the powder in a small glycerin or propanediol slurry before bringing it to the main batch to avoid clumping at high loadings, and keep in mind that above 5% the active becomes a meaningful share of finished-product COGS — the marketing claim and the use level need to line up before scaling. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale lots run on the standard OEM cycle once a carrier is locked. Snap-8 stacks naturally with Matrixyl and GHK-Cu in multi-active serums; the three address distinct dermal-aging mechanisms rather than redundant ones.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.

Applications & formulation fit

Specifications

CAS

868844-74-0

Purity (HPLC)

≥ 99.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request (kilo-scale available)

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Independent analytical report

This SNAP-8 preview matches the catalog product and 10 mg strength. Contact sales with the report number for the complete high-resolution file.

Third-party testView report record →

SNAP-8

10 mg · HPLC / MS

NP810-20260810S6595

Third-party testing in Tianjin

Independent HPLC and mass-spectrometry reports from Qorix , the professional, authoritative third-party analytical laboratory at tjqxgd.com, affiliated with the Tianjin International Joint Academy of Biomedicine.

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions