Hexapeptide-11

Overview

On the INCI deck this active reads as Hexapeptide-11 — the six-residue peptide derived originally from a Saccharomyces yeast-fermentation route. The sequence Phe-Val-Ala-Pro-Phe-Pro (C36H48N6O7, MW 676.80) is a signal peptide studied around skin firmness and elasticity, with the marketed narrative leaning on the appearance of resilience and overall skin condition rather than the wrinkle-relaxation or brightening routes elsewhere in the range. For a finished-product brand it is the active that lets a firming or anti-aging serum carry an elasticity-support story framed at the 'designed to support' level. Pepoderma writes the Hexapeptide-11 spec for cosmetic chemists building firming and anti-aging serums and richer creams where a water-soluble signal peptide drives the formulation work. The active goes into the water phase cool and late on copper-clean process water; near-neutral carriers (pH 5.5–7.0) on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave well, and pre-dissolving the powder in a small glycerin or propanediol slurry keeps it dispersing cleanly. Because it sits in the firmness-and-elasticity signal lane, a brief can layer it with a collagen-leaning matrikine (Matrixyl, Hexapeptide-9) or an elastin-fragment peptide (Palmitoyl Hexapeptide-12) for a broader firmness claim, or pair it with a neurotransmitter peptide (SNAP-8) and a carrier peptide (GHK-Cu) for a multi-axis stack. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle once a carrier is locked. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.

Applications & formulation fit

Specifications

CAS

161258-30-6

Molecular Formula

C36H48N6O7

Molecular Weight

676.80

Sequence

Phe-Val-Ala-Pro-Phe-Pro

Purity (HPLC)

≥ 98.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request (kilo-scale available)

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions