Palmitoyl Hexapeptide-12

Overview

On the INCI deck this active reads as Palmitoyl Hexapeptide-12 — the lipidated hexapeptide commercialised under names such as Biopeptide EL. It is a signal peptide: the sequence Pal-Val-Gly-Val-Ala-Pro-Gly (C38H68N6O8, MW 736.98) carries a palmitoyl tail for stratum-corneum delivery and is built on the 'spring fragment' VGVAPG that repeats through the elastin molecule, which is why the marketed narrative is firmness and skin-conditioning rather than the wrinkle-relaxation or brightening routes elsewhere in the range. For a finished-product brand it is the active that lets a firming serum carry an elastin-fragment story framed at the 'designed to support' level. Pepoderma writes the Palmitoyl Hexapeptide-12 spec for cosmetic chemists building firming and anti-aging serums and richer creams where a single lipidated signal peptide drives the formulation work. Hold pH in the 5.0–7.0 band; alkaline drift hydrolyses the palmitoyl amide bond and a hydrolysed lot loses both its delivery story and its INCI integrity. The palmitoyl tail rewards oil-phase or co-solvent loading rather than a straight water add — pre-disperse in a polysorbate or polyglyceryl blend at moderate temperature, then carry it in on the cool-down train. Because it sits in the elastin-fragment signal lane, a brief can layer it with a collagen-leaning matrikine (Matrixyl, Hexapeptide-9) for a broader firmness claim, or pair it with a neurotransmitter peptide (SNAP-8, Argireline) and a carrier peptide (GHK-Cu) for a multi-axis anti-aging stack. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle once a carrier is locked. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.

Applications & formulation fit

Specifications

CAS

171263-26-6

Molecular Formula

C38H68N6O8

Molecular Weight

736.98

Sequence

Pal-Val-Gly-Val-Ala-Pro-Gly

Purity (HPLC)

≥ 99.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request (kilo-scale available)

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions