Acetyl Tetrapeptide-2

Overview

On the INCI deck this active reads as Acetyl Tetrapeptide-2 — the N-acetylated tetrapeptide commercialised under names such as Peptigravity. The sequence Ac-Lys-Asp-Val-Tyr (C26H39N5O9, MW 565.62) is a signal peptide studied around a proposed thymopoietin-mimetic mechanism, with the marketed narrative leaning on skin firmness, facial-contour support, and the 'lifting' story rather than the expression-line or copper-carrier routes elsewhere in the range. For a finished-product brand it is the active that lets a firming serum or neck-and-décolleté treatment carry a contour-support claim framed at the 'designed to support' level. Pepoderma writes the Acetyl Tetrapeptide-2 spec for cosmetic chemists building firming serums, neck-and-décolleté treatments, and richer anti-aging creams where a water-soluble signal peptide drives the formulation work. The active goes into the water phase cool and late on copper-clean process water; near-neutral carriers (pH 5.5–7.0) on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave well, and pre-dissolving the powder in a small glycerin or propanediol slurry keeps it dispersing cleanly at higher loadings. Because its proposed mechanism differs from the matrikine and neurotransmitter peptides, a brief can layer it with a matrikine (Matrixyl, Matrixyl 3000) for a broader firmness claim or pair it with a carrier peptide (GHK-Cu) for a multi-axis stack. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle once a carrier is locked. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.

Applications & formulation fit

Specifications

CAS

757942-88-4

Molecular Formula

C26H39N5O9

Molecular Weight

565.62

Sequence

Ac-Lys-Asp-Val-Tyr

Purity (HPLC)

≥ 99.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request (kilo-scale available)

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions