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Acetyl Tetrapeptide-2 (Peptigravity) · firmness signal active
Overview
On the INCI deck this active reads as Acetyl Tetrapeptide-2 — the N-acetylated tetrapeptide commercialised under names such as Peptigravity. The sequence Ac-Lys-Asp-Val-Tyr (C26H39N5O9, MW 565.62) is a signal peptide studied around a proposed thymopoietin-mimetic mechanism, with the marketed narrative leaning on skin firmness, facial-contour support, and the 'lifting' story rather than the expression-line or copper-carrier routes elsewhere in the range. For a finished-product brand it is the active that lets a firming serum or neck-and-décolleté treatment carry a contour-support claim framed at the 'designed to support' level. Pepoderma writes the Acetyl Tetrapeptide-2 spec for cosmetic chemists building firming serums, neck-and-décolleté treatments, and richer anti-aging creams where a water-soluble signal peptide drives the formulation work. The active goes into the water phase cool and late on copper-clean process water; near-neutral carriers (pH 5.5–7.0) on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave well, and pre-dissolving the powder in a small glycerin or propanediol slurry keeps it dispersing cleanly at higher loadings. Because its proposed mechanism differs from the matrikine and neurotransmitter peptides, a brief can layer it with a matrikine (Matrixyl, Matrixyl 3000) for a broader firmness claim or pair it with a carrier peptide (GHK-Cu) for a multi-axis stack. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle once a carrier is locked. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.
Who buys this, and why
Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — ship primarily to indie beauty brand founders building retail serums, established skincare R&D chemists extending an existing anti-wrinkle line, and med-aesthetic brand OEMs developing back-bar retail products. The defining formulation considerations are use-level optimisation (lower is often better at the working pH), carrier selection (aqueous vs. lipid-encapsulated), and chelator-free preservative systems. The data packet ships with guidance on all three on the lot report.
Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.
Applications & formulation fit
A signal peptide: Acetyl Tetrapeptide-2 (Ac-Lys-Asp-Val-Tyr) is studied around a proposed thymopoietin-mimetic mechanism, framed around skin firmness and facial-contour support.
Use levels, pH window, and carrier compatibility are covered in the Journal — verify them against your own base:
Specifications
Documentation available on request
Regulatory note
Supplied as a cosmetic-grade peptide active under the EU EC 1223/2009 cosmetic regulation, NMPA cosmetic ingredient framework, FDA OTC monograph framework (where applicable), and equivalent regimes elsewhere. NOT a finished cosmetic product. Brand registration, finished-product safety substantiation, claim documentation, and notification (CPNP for EU, equivalent registries elsewhere) remain the responsibility of the brand owner. INCI naming and CAS are supplied with the SDS that ships with every lot.
Frequently asked questions
It is a signal peptide like the Matrixyl family, but it is studied around a different proposed mechanism — a thymopoietin-mimetic route framed around firmness and facial-contour support — whereas the Matrixyl peptides are matrikine fragments. That lets a brand position Acetyl Tetrapeptide-2 as a complementary firmness-and-contour active alongside Matrixyl or Matrixyl 3000 rather than a duplicate, useful for a neck-and-décolleté or 'lifting' SKU. The framing stays at the 'studied / designed to support' level — a cosmetic firmness narrative, not an efficacy or treatment claim. Put the INCI name and CAS 757942-88-4 on the PO; the Peptigravity trade name maps to Acetyl Tetrapeptide-2.
Add it to the water phase cool and late on copper-clean process water at a near-neutral pH (5.5–7.0), in anionic or non-ionic emulsions or a hydrogel; pre-dissolving the powder in a small glycerin or propanediol slurry avoids clumping at the higher loadings a firming serum can run. As with any cosmetic peptide it does not self-preserve, so the preservation system has to hold the whole product. Use-level and pH specifics are best verified against your own base; our emulsion-stability guide covers the carrier work rather than us restating a single figure here.
Sample fills are 10 mg for first-pass bench iterations and 100 mg once a carrier is selected and stability work begins; brand programmes scale to kilo lots on the standard OEM cycle. Every shipment carries the INCI name (Acetyl Tetrapeptide-2), the CAS, an allergen and trace-impurity statement for CPNP and equivalent cosmetic notifications, and a formulation-notes card. We supply the cosmetic-grade ingredient and its ingredient-level documentation; finished-product registration and claims substantiation remain the brand owner's responsibility.
Related peptides
5-mer
Palmitoyl pentapeptide-4
Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 matrikine blend
3-mer
Copper tripeptide-1
