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Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 matrikine blend
Overview
On the INCI deck this active reads as a blend — Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 — the two-matrikine combination commercialised by Sederma as Matrixyl 3000. Both components are lipidated signal peptides (matrikines): the palmitoyl tail on each turns a polar, bench-shy peptide into a stratum-corneum-friendly amphipath, and the pairing is designed so two matrix-signalling fragments work side by side rather than one alone. The story a firmness-and-collagen brand can tell on pack is a matrikine-messaging one — a proposed signal to dermal fibroblasts to support collagen and the wider matrix — distinct from the single-peptide Matrixyl (Palmitoyl Pentapeptide-4) the brand may already carry. Pepoderma writes the Matrixyl 3000 spec for cosmetic chemists building collagen-support and firming serums and richer night creams, where two lipidated peptides in one blend create real formulation work. Hold pH in the 5.0–7.0 band; alkaline drift hydrolyses the palmitoyl amide bonds and a hydrolysed lot loses its delivery story along with its INCI integrity. The hydrophobic tails reward oil-phase or co-solvent loading rather than a straight water add — pre-disperse in a polysorbate or polyglyceryl blend at moderate temperature, then bring it down with the cool-down train. Because it is a defined two-component blend, the documentation reflects both INCI names and both CAS numbers, and a brief should specify 'Matrixyl 3000' (the blend) rather than 'Matrixyl' to avoid being quoted the single Palmitoyl Pentapeptide-4 by mistake. Matrixyl 3000 stacks cleanly with SNAP-8 or Argireline (a neurotransmitter arm) and GHK-Cu (a carrier arm) because the three address distinct dermal-aging axes. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications.
Who buys this, and why
Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — ship primarily to indie beauty brand founders building retail serums, established skincare R&D chemists extending an existing anti-wrinkle line, and med-aesthetic brand OEMs developing back-bar retail products. The defining formulation considerations are use-level optimisation (lower is often better at the working pH), carrier selection (aqueous vs. lipid-encapsulated), and chelator-free preservative systems. The data packet ships with guidance on all three on the lot report.
Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.
Applications & formulation fit
A signal-peptide complex (matrikines): palmitoyl Pal-GHK plus Pal-GQPR, two lipidated matrix fragments that cross the stratum corneum and signal dermal fibroblasts toward matrix support — the most widely formulated peptide complex in anti-aging.
Use levels, pH window, and carrier compatibility are covered in the Journal — verify them against your own base:
Specifications
Documentation available on request
Regulatory note
Supplied as a cosmetic-grade peptide active under the EU EC 1223/2009 cosmetic regulation, NMPA cosmetic ingredient framework, FDA OTC monograph framework (where applicable), and equivalent regimes elsewhere. NOT a finished cosmetic product. Brand registration, finished-product safety substantiation, claim documentation, and notification (CPNP for EU, equivalent registries elsewhere) remain the responsibility of the brand owner. INCI naming and CAS are supplied with the SDS that ships with every lot.
Frequently asked questions
They are different products on a bench even though the names blur on a brief. The original Matrixyl is Palmitoyl Pentapeptide-4 — a single lipidated KTTKS molecule. Matrixyl 3000 is a defined blend of two matrikine peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, dosed and documented as a combination. Because they are regulated and formulated differently, a PO that just says 'Matrixyl' tends to end in an expensive sample swap, so specify the product name and the component INCI names. Pepoderma supplies the original Palmitoyl Pentapeptide-4 as a separate SKU and the Matrixyl 3000 two-peptide blend here; both run on the lipidated-peptide analytical workflow.
Each component carries a palmitoyl tail that makes the molecule amphipathic: the lipid partitions into the stratum-corneum lipids so the peptide moiety can reach the viable epidermis where fibroblasts sense the signal. That same hydrophobicity means a straight water add tends to form agglomerates, so the blend is best pre-dispersed in a small polysorbate or polyglyceryl co-solvent slurry at moderate temperature, then carried into the batch on the cool-down. Keep pH in the 5.0–7.0 band — alkaline drift hydrolyses the palmitoyl amide bonds and gives a stability programme a second-peak problem on HPLC. Our emulsion-stability and layering guides cover the carrier specifics to verify against your own formula.
Because Matrixyl 3000 is a blend, the documentation reflects both component INCI names (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7) and both CAS numbers (147732-56-7 and 221227-05-0) on the SDS for CPNP and equivalent cosmetic notifications, alongside an allergen and trace-impurity statement per lot. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; brand programmes scale on the standard OEM cycle once a carrier is locked. We supply the cosmetic-grade ingredient blend and its ingredient-level documentation; finished-product claims and registration remain the brand owner's responsibility.
Related peptides
5-mer
Palmitoyl pentapeptide-4
15-mer
Palmitoyl Tripeptide-38 · matrikine signal active
Acetyl octapeptide-3 · cosmetic peptide
