Matrixyl Synthe'6

Overview

On the INCI deck this active reads as Palmitoyl Tripeptide-38 — the lipidated tripeptide commercialised by Sederma as Matrixyl Synthe'6. It is a signal peptide (matrikine): the sequence Pal-Lys-Met(O2)-Lys-OH carries a palmitoyl tail for stratum-corneum delivery and is studied around a proposed multi-target matrix signal, with the marketed narrative spanning collagen I, III and IV, fibronectin, and hyaluronic acid. For a fine-line and smoothing brand the on-pack story is a matrix-rebuilding signal framed at the 'designed to support' level — a complement to, rather than a duplicate of, the Matrixyl (Palmitoyl Pentapeptide-4) and Matrixyl 3000 entries a brand may already carry. Pepoderma writes the Matrixyl Synthe'6 spec for cosmetic chemists building fine-line, firming, and smoothing serums and richer creams where a single lipidated matrikine drives the formulation work. Hold pH in the 5.0–7.0 band; alkaline drift hydrolyses the palmitoyl amide bond and a hydrolysed lot loses both its delivery story and its INCI integrity. The palmitoyl tail rewards oil-phase or co-solvent loading rather than a straight water add — pre-disperse in a polysorbate or polyglyceryl blend at moderate temperature, then carry it in on the cool-down train. Because it is a distinct matrikine from the other Matrixyl-family peptides, a brief can layer it with them for a broader matrix-signal claim, or pair it with a neurotransmitter peptide (SNAP-8, Argireline) and a carrier peptide (GHK-Cu) for a multi-axis anti-aging stack. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.

Applications & formulation fit

Specifications

CAS

1447824-23-8

Sequence

Pal-Lys-Met(O2)-Lys-OH

Purity (HPLC)

≥ 99.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions