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Dipeptide Diaminobutyroyl Benzylamide Diacetate · expression-line active
Overview
On the INCI deck this active reads as Dipeptide Diaminobutyroyl Benzylamide Diacetate — the synthetic small-molecule peptidomimetic marketed as SYN-AKE, designed as a mimetic of waglerin-1, a peptide originally identified in temple-viper venom. Where the Argireline/SNAP-8 family is studied around the SNARE/SNAP-25 pathway, SYN-AKE is studied as a proposed antagonist at the postsynaptic muscle-type nicotinic acetylcholine receptor (nAChR) — a different node on the same broad expression-line story. The structure H-βAla-Pro-Dab-NHBzl (MW 495.56) is compact and water-soluble, which is part of why the molecule reads cleanly on a lightweight serum or eye-area gel deck rather than a rich emulsion. Pepoderma writes the SYN-AKE spec for cosmetic chemists building dynamic-line serums, eye creams, and smoothing primers that want a neuromuscular-pathway narrative distinct from the SNARE peptides. The active goes into the water phase cool and late on copper-clean process water; near-neutral carriers (pH 5.5–7.0) on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave predictably, and the molecule's low molecular weight means it disperses without the slurry pre-step heavier lipidated peptides need. Because it engages a different receptor target from the acetyl-hexapeptide class, a brief can position SYN-AKE alongside Argireline or SNAP-8 as a complementary mechanism in a multi-vector expression-line claim rather than a redundant one — keep both in the aqueous phase and let the cool-down order do the work. Sample fills of 10 mg and 100 mg cover bench iterations and pilot trials; kilo-scale runs on the standard OEM cycle once a carrier is locked. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic-notification workflows, with an allergen and trace-impurity sheet on every lot.
Who buys this, and why
Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — ship primarily to indie beauty brand founders building retail serums, established skincare R&D chemists extending an existing anti-wrinkle line, and med-aesthetic brand OEMs developing back-bar retail products. The defining formulation considerations are use-level optimisation (lower is often better at the working pH), carrier selection (aqueous vs. lipid-encapsulated), and chelator-free preservative systems. The data packet ships with guidance on all three on the lot report.
Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.
Applications & formulation fit
A neurotransmitter-inhibiting peptide: a synthetic, remodelled mimetic of the waglerin-1 motif that reversibly engages the muscular nicotinic acetylcholine receptor — an expression-line route distinct from the SNAP-25 peptides.
Use levels, pH window, and carrier compatibility are covered in the Journal — verify them against your own base:
Specifications
Documentation available on request
Regulatory note
Supplied as a cosmetic-grade peptide active under the EU EC 1223/2009 cosmetic regulation, NMPA cosmetic ingredient framework, FDA OTC monograph framework (where applicable), and equivalent regimes elsewhere. NOT a finished cosmetic product. Brand registration, finished-product safety substantiation, claim documentation, and notification (CPNP for EU, equivalent registries elsewhere) remain the responsibility of the brand owner. INCI naming and CAS are supplied with the SDS that ships with every lot.
Frequently asked questions
All three sit in the broad expression-line category, but they are studied around different molecular targets. Argireline (Acetyl Hexapeptide-8) and SNAP-8 (Acetyl Octapeptide-3) are proposed to act on the SNARE complex via SNAP-25, on the presynaptic side of neurotransmitter release. SYN-AKE is a synthetic waglerin-1 mimetic studied as a proposed antagonist at the postsynaptic muscle-type nicotinic acetylcholine receptor. Because the proposed targets differ, a formulator can frame SYN-AKE as a complementary mechanism in a multi-vector expression-line serum rather than a substitute for the acetyl-hexapeptide peptides — useful for a brand that wants a distinct mechanistic story on pack. The framing should stay at the 'studied / proposed' level; this is a cosmetic active, not an injectable treatment.
It simplifies the water-phase add. At MW 495.56 the molecule is compact and water-soluble, so it disperses without the co-solvent slurry that heavier lipidated peptides like the Matrixyl family need to avoid agglomeration. Add it cool and late on copper-clean process water at a near-neutral pH (5.5–7.0), in anionic or non-ionic emulsions or a hydrogel. As with any cosmetic peptide it does not self-preserve, so the preservation system has to hold the whole formula. For use-level and pH specifics, verify against your own base using our wrinkle-peptide comparison guide rather than a single supplier figure.
Sample fills are 10 mg for first-pass bench work and 100 mg once you are locking the carrier and starting stability; brand programmes scale to kilo lots on the standard OEM cycle. Each shipment carries the INCI name (Dipeptide Diaminobutyroyl Benzylamide Diacetate), the CAS, an allergen and trace-impurity statement for CPNP and equivalent cosmetic notifications, and a formulation-notes card. Finished-product registration and claims substantiation remain the brand owner's responsibility; we supply the cosmetic-grade ingredient and its ingredient-level documentation.
Related peptides
22-mer
Acetyl Hexapeptide-8 · expression-line active
Acetyl octapeptide-3 · cosmetic peptide
16-mer
Pentapeptide-18 · expression-line active
