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Acetyl Hexapeptide-30 (Inyline) · expression-line active
Overview
On the INCI deck this active reads as Acetyl Hexapeptide-30 — the N-acetylated hexapeptide commercialised as Inyline. It is a neurotransmitter-pathway peptide studied as a proposed competitive antagonist at muscle-specific kinase (MuSK), modulating neuromuscular-synapse signalling — a route that is related to, but distinct from, the SNAP-25/SNARE pathway the Argireline and SNAP-8 family engage. For a finished-product brand it is the active that lets an expression-line serum or pre-makeup primer carry a wrinkle-softening story on a complementary neuromuscular pathway, framed at the 'studied / designed to support' level. It is listed in the EU CosIng inventory; suppliers commonly ship it without a single assigned CAS, so Pepoderma documents identity by INCI plus the batch COA rather than guessing a number. Pepoderma writes the Acetyl Hexapeptide-30 spec for cosmetic chemists building expression-line serums, eye creams, and pre-makeup smoothing primers that want a neuromuscular-pathway narrative distinct from the SNAP-25 peptides. The active drops into the water phase cool and late on copper-clean process water; near-neutral carriers (pH 5.5–7.0) on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave well, and pre-dissolving the powder in a small glycerin or propanediol slurry keeps it dispersing cleanly at the higher loadings the category runs. Because it engages a different proposed target from the acetyl-hexapeptide SNARE peptides, a brief can position it alongside Argireline or SNAP-8 as a complementary mechanism in a multi-vector expression-line claim rather than a redundant one. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle once a carrier is locked. INCI and the lot identity appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.
Who buys this, and why
Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — ship primarily to indie beauty brand founders building retail serums, established skincare R&D chemists extending an existing anti-wrinkle line, and med-aesthetic brand OEMs developing back-bar retail products. The defining formulation considerations are use-level optimisation (lower is often better at the working pH), carrier selection (aqueous vs. lipid-encapsulated), and chelator-free preservative systems. The data packet ships with guidance on all three on the lot report.
Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.
Applications & formulation fit
A neurotransmitter-pathway peptide: Acetyl Hexapeptide-30 (Inyline) is studied as a proposed competitive antagonist at muscle-specific kinase (MuSK), a postsynaptic neuromuscular node distinct from the SNAP-25 route of the Argireline/SNAP-8 peptides.
Use levels, pH window, and carrier compatibility are covered in the Journal — verify them against your own base:
Specifications
Documentation available on request
Regulatory note
Supplied as a cosmetic-grade peptide active under the EU EC 1223/2009 cosmetic regulation, NMPA cosmetic ingredient framework, FDA OTC monograph framework (where applicable), and equivalent regimes elsewhere. NOT a finished cosmetic product. Brand registration, finished-product safety substantiation, claim documentation, and notification (CPNP for EU, equivalent registries elsewhere) remain the responsibility of the brand owner. INCI naming and CAS are supplied with the SDS that ships with every lot.
Frequently asked questions
All three sit in the broad expression-line category, but they are studied around different proposed targets. Argireline (Acetyl Hexapeptide-8) and SNAP-8 (Acetyl Octapeptide-3) are studied on the SNARE complex via SNAP-25, on the presynaptic side. Acetyl Hexapeptide-30 (Inyline) is studied as a proposed competitive antagonist at muscle-specific kinase (MuSK), a postsynaptic neuromuscular node. Because the proposed targets differ, a formulator can frame Acetyl Hexapeptide-30 as a complementary mechanism in a multi-vector expression-line serum rather than a substitute for the SNARE peptides. The framing stays at the 'studied / designed to support' level; this is a cosmetic active, not an injectable treatment.
Acetyl Hexapeptide-30 is an established INCI name listed in the EU CosIng inventory, but it does not have a single, widely agreed public CAS number in the way GHK-Cu (89030-95-5) or Argireline (616204-22-9) do — suppliers routinely ship it documented by INCI and lot rather than a registry CAS. In keeping with our no-guessing rule, Pepoderma states identity via the INCI name and the certificate of analysis for the specific lot rather than printing a CAS we cannot stand behind. Brands that need a registry identifier for a particular market notification should raise it at quote stage so we can confirm what the lot's COA carries before you build the dossier.
Sample fills are 10 mg for first-pass bench iterations and 100 mg once a carrier is selected and stability work begins; brand programmes scale to kilo lots on the standard OEM cycle. Every shipment carries the INCI name (Acetyl Hexapeptide-30), the lot identity and certificate of analysis, an allergen and trace-impurity statement for CPNP and equivalent cosmetic notifications, and a formulation-notes card. Note that under some market frameworks this INCI carries a maximum-use constraint, so confirm the destination market's rule as part of your finished-product registration. We supply the cosmetic-grade ingredient and its ingredient-level documentation; finished-product claims substantiation remains the brand owner's responsibility.
Related peptides
22-mer
Acetyl Hexapeptide-8 · expression-line active
Acetyl octapeptide-3 · cosmetic peptide
15-mer
Dipeptide Diaminobutyroyl Benzylamide Diacetate · expression-line active
