Eyeseryl

Overview

On the INCI deck this active reads as Acetyl Tetrapeptide-5 — the N-acetylated tetrapeptide commercialised as Eyeseryl, written specifically for the eye contour. The sequence Ac-βAla-His-Ser-His is studied around proposed anti-oedema and vascular-permeability mechanisms, which is why the marketed positioning is under-eye puffiness and the periocular smoothing story rather than the dynamic forehead and glabellar lines the expression-line peptides target. For a brand building an eye-area SKU it is the active that lets the claim language stay specifically about the eye contour. Pepoderma writes the Eyeseryl spec for cosmetic chemists building eye serums, eye gels, and de-puffing eye creams where a water-soluble peptide and a delicate application area shape the formulation. The active goes into the water phase cool and late on copper-clean process water; near-neutral carriers (pH 5.5–7.0) on polyglyceryl, lecithin, or sucrose-ester emulsifiers behave well, and lightweight hydrogel and roll-on eye-area bases suit it. Because the eye contour is a sensitive zone, the surrounding formula — preservative system, surfactant load, fragrance — deserves the same scrutiny as the active itself; the peptide does not self-preserve, so the preservation strategy has to hold the whole product. Eyeseryl pairs naturally with GHK-Cu or AHK-Cu in a periocular gel and with SNAP-8 or Argireline when an eye SKU wants both a puffiness arm and an expression-line arm. Sample fills of 10 mg and 100 mg cover bench iterations and pilot work; kilo-scale runs on the standard OEM cycle. INCI and CAS appear on the SDS for CPNP and equivalent cosmetic notifications, with an allergen and trace-impurity sheet per lot.

Who buys this, and why

Anti-aging peptide actives — Copper Tripeptide-1 (GHK-Cu), Acetyl Octapeptide-3 (SNAP-8), Palmitoyl Pentapeptide-4 (Matrixyl) — are sourced by beauty brands, skincare R&D chemists, and med-aesthetic OEMs. Ask sales for the matching batch COA and confirm which use-level, carrier, compatibility, or stability records are available or need a separate written scope.

Primary buyer fit: med-aesthetic brand R&D + back-bar retail OEM and regional cosmetic-active distributors serving brand programmes.

Applications & formulation fit

Specifications

CAS

820959-17-9

Sequence

Ac-βAla-His-Ser-His

Purity (HPLC)

≥ 99.0%

Common vial sizes

10 mg, 100 mg

MOQ

On request

Lead time

10–18 days

Storage

Refrigerated, protect from light

Documentation available on request

• Lot-specific Certificate of Analysis (CoA)
• RP-HPLC purity chromatogram
• ESI-MS identity confirmation
• INCI name + CAS reference
• Recommended use level + carrier guidance
• Stability in base formulation (aqueous serum baseline)
• Incompatibility flag list (chelators, low-pH oxidants, etc.)
• SDS / MSDS
• Photo-degradation note for the active
• Reconstitution guidance (BAC water / glycerin / lipid-encapsulated)

Regulatory note

Supplied as a cosmetic peptide active, not a finished cosmetic product. Brand registration, finished-product safety substantiation, claims, and notification remain the responsibility of the brand owner. Confirm the applicable INCI, CAS, and SDS with sales for the offered lot and written project scope.

Frequently asked questions